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Cost of atorvastatin 20 mg, which also requires a 2-year double-blind phase to assess safety and tolerability before inclusion in clinical practice.[8] The safety and tolerability profile of simvastatin has also been examined in several short-term, 3-week clinical trials (15 patients each). In these trials, subjects were randomized to receive simvastatin 20 mg as an initial treatment, then continued on a maintenance dose of simvastatin 20 mg plus clopidogrel for an additional 18 weeks. There was one clinical serious (incidence rate of 3-7%) event in the study including two cardiac events. The long-term safety and efficacy in multiple-dose, open-label trials of simvastatin have also been evaluated. In a randomized 3-month trial, simvastatin 80 mg alone or with ribavirin (500 mg every 4 hours) was associated with a reduction from baseline of 9-11 mm Hg (18%) for the first 6 months and 11.6-13.6 mm Hg (21%) for the second year of treatment.[9] In a 3-month open-label trial simvastatin was associated with a reduction in major adverse events (AEs) from placebo of 4% for the first 6 months of treatment (95% confidence interval 3% to 7%) and 9% for the second 6 months (95% confidence interval 6% to 11%). Taken together, these studies suggest that simvastatin has a superior safety and efficacy profile relative to other AEs. Efficacy of AEs for the Treatment IHD Aetna believes that the reduction in high-dose aspirin use with simvastatin provides a beneficial effect on the health care system because of the reduced number patients, higher proportion of patients taking the aspirin-free simvastatin regimen, and lower level of aspirin-related morbidity.[10] A total 14 clinical trials were analyzed to evaluate efficacy of simvastatin or any AEs for the treatment of IHD in adults addition to the main treatment regimen. All studies were powered to detect a mean reduction in mortality of 7% or fewer (20% to 40%), using a 95% confidence interval, and achieved a mean reduction in the composite primary end point of 10%-25% (6%-20%). In several small trials, simvastatin 20 mg or 25 with clopidogrel had a greater response rate than simvastatin 10 mg or 25 with lovastatin (Table 6). The reduction in risk of IHD events was 0.45% at an LDL-C level of 70 mg/dL and 0.60% at 90 mg/dL. A similar reduction in the risk of IHD events was observed with an atorvastatin 40 mg cost increase to 300 mg/dL (25 mg aspirin and 150 mg/dL with clopidogrel). A reduction was demonstrated with simvastatin 200 mg (20 aspirin, 400 mg/dL with clopidogrel) to all IHD endpoint measures including lower LDL-C level, nonfatal MI, and acute coronary events. A lower risk of death was seen with simvastatin 10 mg and 25 with ribavirin (10 mg, 400 mg/dL).[11] In addition, a reduction the risk of death was seen when simvastatin 25 mg with ribavirin (500 mg/5 days simvastatin) was compared with simvastatin 20 mg. However, this benefit was not seen in a randomized trial with Ator 90 20mg - $350 Per pill simvastatin 50 mg (20 aspirin, 600 mg/6 days with ribavirin) clopidogrel. Simvastatin 20 mg had a greater reduction in the incidence of deaths from all causes than simvastatin 50 mg.[12] In contrast, mg had a greater benefit with respect to the incidence of acute coronary events than simvastatin 20 mg in a randomized clinical trial.[13] Table 6. Summary of Antithrombotic Drugs Approved by the United States Food and Drug Administration for the Treatment of Hypertension in Adults Dosing Status FDA Status Generic Dose Range (mg/day) Simvastatin 50 mg 200 50-700 Doses with Ribavirin 300-1800 Fluvastatin* 800-1000 Antithrombotic Drugs Approved by the United States Food and Drug Administration for the Treatment of Hypertension in Adults Dosing StatusFDA Status Generic Dose Range (mg/day) Simvastatin 50 mg 200 50-700 Doses with Ribavirin 300-1800 Fluvastatin* 800-1000 View Large Table 6. Summary of Antithrombotic Drugs Approved by the United States Food and Drug Administration for the Treatment of Hypertension in Adults D.

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Cost Of Atorvastatin 40 Mg Uk
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